The Methuselah Gene

Biotech is big business. Now a giant called Celgene is investing in biotech’s future by buying Impact BioMedicines with a $7 Billion ante up. Good investment? Well, biobucks are hotter than Bitcoin, long term. More money than opioids. Just watch any network news report, the second half of which is all pharmaceuticals, with side effects. Development takes years and billions, and the payoffs are big, and losses also. (My sister has cancer, and her meds just on insurance co-pay were $500 a week. Didn’t help. Now she’s on Hospice.) Drug patents expire, rivals vie for space, with mergers and acquisitions the ultimate power play. Congress is trying to deregulate everything from the EPA to the DEA. It’s a “go big or go home” strategy. The cancer drug Jakafi is a huge seller for two other pharmaceutical giants, and Celgene wants to compete. They want in, and are into Immunotherapy too. On the ropes with their own drug expiring soon, they have little choice. The CEO touts the future of using genetic engineering to attach genes to molecules, similar to what Ron Howard’s show Breakthroughs reported a year or so ago in which a neutered HIV targeted cancers past the blood/brain barrier.  Meanwhile, supplements like Nugenix is being hyped to athletes to improve testosterone. Is there a dark side to biotech? “CRISPR” (pronounced “crisper”) stands for Clustered Regularly Interspaced Short Palindromic Repeats, which are the hallmark of a bacterial defense system that forms the basis for CRISPR-Cas9 genome editing technology. It may soon be possible to eliminate certain diseases genetically, to change the eye color (and more) of babies, and to lengthen the lifespan of humans. Many strides have already been made, such as the means to fight cancer using gene therapy. To some, this is all “playing God,” while to others it is progress: the “search for better explanations, leading to discoveries,” as David Deutsch put it in “The Beginning of Infinity.” Whatever the technology, there are problems, as discussed in the book on social media interfaces: “Dawn of the New Everything” by Jaron Lanier. In my novel “The Methuselah Gene” a neutered HIV is used, not as a cancer therapy, but to implant a longevity gene taken from a bristlecone pine tree past the blood/brain barrier, and extend human life by decades. A pill to do something like this is now in the works, and may be here within a decade. How much would such a pill cost, and will only the super rich be able to afford it? In the New Rules governing culture, before young icons can imagine near immortality via science, what if nefarious forces tested it on a small town without their knowledge or consent…and discovered that there were side effects?

Jonathan Lowe

 

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Fires and Floods

wallow fireIt was sad, the fire around Alpine AZ…I was just recalling it with my sister, who has brain cancer. And what an incredible place that was…so pristine, little traffic, vast forests…I saw a wolf and then a family of 7 deer in the road.  I had just driven through there on my way back to SC for the summer, and was warned by someone at a gas station not to take highway 191 up to i40 because of all the switchbacks (“it’s a huge waste of time” he said).  I took the road anyway, this road not taken, and was amazed….one of the most beautiful roads I’ve ever seen.  Didn’t pass a single car the first 50 miles, heading north through mountain wilderness.  When I came to Alpine it was so incredible I was even wondering how it might be possible to live there, and then I pick up the paper here in SC the other day, and see that it’s about to be engulfed in flames. Now such fires are commonplace and getting worse. I just can’t imagine driving back that way. Perhaps those trees, some of them, have grown back since 2011. Many of the biggest and oldest were reduced to ash. I thought of Avatar, caused by some careless camper or arsonist. Or lightning. Of course the East sees floods, from Texas to New England. Florida? The Sunshine State is often flooded as well. What’s next? 

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The Physics of Telescope Mirrors

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In A Hitchhiker’s Guide to the Galaxy, Arthur Dent is confronted by the prospect of the Earth being destroyed to make way for a hyperspace bypass. In countless movies like Star Wars, the universe is depicted as a crowded arena swarming with irate creatures, many of which somehow possess two eyes, two ears, two arms, two legs and a penchant for motor sports.

What’s the truth of it? Well, the answer may indeed be out there; just don’t expect to find it by asking a Hollywood screenwriter. To discover the real truth, you’d either need to talk to a working astronomer, or get yourself a pair of very powerful binoculars. Not the kind you can buy at a shopping mall, mind you, but rather one with lenses 28 feet wide.

Believe it or not, such a binocular actually exists. Called the Large Binocular Telescope (LBT), this $120 million, 500-metric-ton instrument is now atop Mount Graham, east of Tucson. One of the most powerful telescope in the world, the device, using two giant 8.4-meter mirrors working in tandem, is able to peer deeper into the past, and with better clarity, than the Hubble Space Telescope.

Project director Dr. Richard Green said viewing is limited “primarily to those astronomers in the partner institutions that funded the project.” So unless you’re a qualified scientist from the University of Arizona or one of its partners, you can’t use the telescope.

Even for astronomers, finding time on a major telescope can be tough. As Dr. Green put it, “The current demand so exceeds availability that only one project in six or eight actually wins time competitively.”

Different research projects also demand different types of telescopes. “Many telescopes are specialized to record celestial radiation in different ways,” said Dr. Green. This includes not just visible light, but infrared and ultraviolet radiation, plus X-rays, gamma rays and simple radio waves. “Then you have the Large Synoptic Survey Telescope (LSST), also being designed in Tucson, but with a much wider field of view than the LBT so that it can capture the night-to-night changes in faint objects to find moving asteroids and distant exploding supernovae. To continue the pace of discovery, we simply need more telescopes, like biologists need more microscopes.”

And in another nod to Southern Arizona, when institutions need the mirrors used in telescopes like the LBT, the LSST or the upcoming Giant Magellan Telescope, they come to Tucson, on campus at the UA’s Steward Observatory Mirror Lab–a state-of-the-art facility that casts the massive slabs of glass destined to answer some of science’s ultimate questions.

Here in this impressive room, behind the university’s Flandrau Science Center, a huge furnace heats 20 tons of glass, gently spinning it into a parabolic shape at 2,130 degrees Fahrenheit, before cooling and polishing it to an accuracy that’s about 3,000 times thinner than a human hair. Finally, a coating of reflective aluminum is applied, and the lighter-weight mirror or mirrors are then transported to the telescope site.

Arizona is a prime place for telescopes, as are spots in Chile, Hawaii and the Canary Islands, because of four needed attributes, according to Dr. Green: clear skies, dark skies, naturally sharp celestial imaging and low water vapor.

“Southern Arizona has an average of about 75 percent clear hours over the course of a year, and Mount Graham is distant enough from Tucson and Phoenix that the growing light pollution from those metro areas has less impact,” Green said. “All the high peaks in Southern Arizona actually deliver sharp images when the weather is stable, but the high altitude of Mount Graham gives especially low water vapor, of particular value for infrared observations, where water in the atmosphere can absorb celestial radiation.”

The three telescopes now atop Mount Graham–the LBT, the Heinrich Hertz Submillimeter Telescope and the Vatican Observatory Telescope–represent the completion of only the first phase of development. More scopes will be coming, Green said. Indeed, the initial vision called for some seven major telescopes on the site, but the UA will need to formulate an approach with the U.S. Forest Service for the next phase, with environmental concerns a factor.

That’s not to say the Kitt Peak National Observatory has been left behind.

“As a mature facility with moderate aperture telescopes, Kitt Peak observatories are assuming a new and complementary role in astronomy,” Green said. “Their two largest telescopes have mirrors of about 4 meters, with very wide fields of view, and are used more for surveying large areas of the sky for rare objects that can then be followed up with the truly giant telescopes like LBT. Kitt Peak also hosts a number of smaller telescopes run by university consortia that support the long-term projects of their faculty and students.”

Indeed, many astronomers at the UA benefit from Kitt Peak data now, and will from LBT data, too. Like Xiaohui Fan, who holds the record for discovering the most distant quasars, and is ready to start his next survey with LBT. Or Phil Hinz, who is working with NASA support to achieve super-Hubble resolution for detection of extra-solar planets. Green himself has been studying quasars and black holes since his own graduate-student days, when he was a member of the science team that built the Hubble Space Telescope instrument that surveyed nearby giant galaxies, and verified a black hole at the center of every one of them.

Meanwhile, excitement over the LBT’s possibilities continues to grow. “The LBT can make images sharp enough to resolve a football at a distance of 4,000 miles,” said Dr. John Hill, LBT’s technical director. “So if it weren’t for the curvature of the Earth, you could use it to watch Steelers games in Pittsburgh.”

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Courtesy GMT.org

(Reprinted from Tucson Weekly, by Jonathan Lowe. Also wrote a cover article for Sky & Telescope.) Novel link.

The Miraculous Plot

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